Find in Library

Algae, bacteria, and fungi, as well as higher plants, produce a wide variety of secondary metabolites known as natural products. Natural products are well known as remarkable sources of many therapeutic agents. The genus <i>Nemania</i> is a wood-decaying fungus that belongs to family Xylariaceae. <i>Nemania</i> is often found as an endophyte in diverse hosts and some species are known to produce useful secondary metabolites. In this study, two <i>Nemania</i> species were isolated as an endophytic fungus from <i>Aquilaria sinensis</i>. Multi-gene phylogenetic studies showed that the newly described strains of <i>Nemania</i> are new to science, and this is the first report of <i>Nemania</i> from the host <i>Aquilaria</i>. One of the fermented species, <i>Nemania aquilariae</i> (KUMCC 20-0268), resulted in five sesquiterpenoids, which were previously reported from agarwood, and their structures were identified by gas chromatography-mass spectrometry (GC-MS). In addition, five different media were investigated in vitro to optimize conditions for growing the fungal biomass of <i>Nemania aquilariae</i> and <i>N. yunnanensis</i>.