Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia

oleh: Felix Jede, Theresa Brandt, Molla Gedefaw, Solomon Berhe Wubneh, Tamrat Abebe, Brhanu Teka, Kassahun Alemu, Binyam Tilahun, Temesgen Azemeraw, Abebaw Gebeyehu, Dietmar Schmidt, Aleksandra Pesic, Andreas M. Kaufmann, Bewketu Abebe, Zelalem Ayichew, Michael Byczkowski, Timoté Vaucher, Heike Sartor, Gashaw Andargie, Till Bärnighausen, Magnus von Knebel Doeberitz, Hermann Bussmann

Format: Article
Diterbitkan: Elsevier 2020-06-01

Deskripsi

Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system is in place.A cervical cancer screening campaign was conducted in a rural community in Ethiopia. All women aged 25–65 years were offered genital self-sampling using the Evalyn Brush®. Samples were HPV-DNA-tested at a central laboratory. Key indicators were captured on tablet computers and linked by a cloud-based information system. HPV-positive women were examined at the local clinic using portable colposcopy, p16/Ki-67 dual stain cytology and biopsy examination. CIN2+ women were referred for LEEP to the referral hospital.Of 749 enumerated age-eligible women 634 (85%, (95% CI 82–88)) consented to screening, 429 samples were adequate for HPV testing, giving a total testing coverage of 57% (95% CI 53–62). The hrHPV prevalence was 14% (95% CI 5–22), 72% (95% CI 60–84) attended the clinic for a triage examination. Home-based HPV-DNA self-sampling and clinic-based triage assisted by cloud-based information technology is feasible in rural Ethiopia. Key components of such strategy are broad community awareness, high competency of community workers, and establishment of an adequate self-sampling and HPV-DNA testing platform.