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Research advances of factors and mechanisms for therapeutic efficacy of rituximab for primary membranous nephropathy
oleh: Yu-ting Liu, Yue Wang
Format: | Article |
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Diterbitkan: | Editorial Department of Journal of Clinical Nephrology 2024-09-01 |
Deskripsi
Primary membranous nephropathy (PMN) is a kidney-specific autoimmune disease mediated by autoantibodies. Although rituximab (RTX) has been widely applied as a first-line treatment for PMN, 20%-40% patients are non-responsive to RTX. High disease activity, severe renal lesions and low RTX bioavailability may be correlated with poor therapeutic response to RTX. Residual B cells in tissues, preservation of CD20 negative B cells, epitopic spreading, disorders of T cells and cytokines are potential mechanisms of RTX-refractory PMN. Elucidation of these factors and potential mechanisms shall help to boost the efficacy of RTX for PMN.