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In manufacturing industries, well-maintained machines ensure their maximum utilization with good product quality, efficient time, and minimum cost. The objective of this study is to investigate a socks manufacturing line to propose an advanced maintenance plan based on Overall Equipment Effectiveness (OEE) to improve the overall maintenance along with better machine performance and product quality. Firstly, a socks manufacturing unit was selected and its maintenance-related problems were identified. It was observed that, among the six big losses, three losses have the major contribution in reducing the world-class value of OEE. Then a framework was designed based on the OEE model with the amalgamation of problem-solving tools to overcome the identified problems and reduce the contribution of three big losses. After the successful implementation of the proposed model, a significant reduction in the value of three big losses was observed that ultimately improve the value of OEE factors for the socks knitting machines by 2.18%. The statistical analysis is also conducted using three types of statistical tests, the Normality test, Wilcoxon signed-rank test, and Paired samples t -test. Kolmogorov–Smirnov (KS) test by Statistical Analysis Software (SAS). This paper points out a new proposed model of advanced OEE, which can improve machine maintenance, productivity, and quality in a better way as compared to the conventional OEE model.