Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants
oleh: Pengcheng Han, Chao Su, Yanfang Zhang, Chongzhi Bai, Anqi Zheng, Chengpeng Qiao, Qing Wang, Sheng Niu, Qian Chen, Yuqin Zhang, Weiwei Li, Hanyi Liao, Jing Li, Zengyuan Zhang, Heecheol Cho, Mengsu Yang, Xiaoyu Rong, Yu Hu, Niu Huang, Jinghua Yan, Qihui Wang, Xin Zhao, George Fu Gao, Jianxun Qi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
The SARS-CoV-2 spike (S) protein mediates viral entry by binding of its receptor-binding domain (RBD) to the human angiotensin-converting enzyme 2 (ACE2) receptor and mutations of the S protein may have a great impact on virus transmissibility. Here, the authors characterize the interactions of six different SARS-CoV-2 RBD variants among them Alpha, Beta and Gamma and present crystal structures of these ACE2-RBD complexes.