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Objective: To analyze the clinical characteristics, laboratory indexes, treatments and outcome of the adult-onset Still's disease(AOSD). Methods: Retrospective analysis of clinical data was made in 26 cases of AOSD from Jan. 2010 up to present. Results: The main features of AOSD included high fever, skin rash, polyarthralgia, sore throat, lymphadenopathy, hepatosplenomegaly and elevated circulating levels of liver enzymes. Other changes in laboratory tests were elevations in white blood cell counts, neutrophils, erythrocyte sedimentation rate and serum ferritin, along with decreased hemoglobin. In addition to the treatment with nonsteroidal anti-inflammatory drugs, 24 cases were also treated with glucocorticoids, while 4 and 2 cases were given methotrexate and thunder god vine, respectively. One case died. Conclusions: The main manifestations of AOSD are fever, skin rash, arthralgia, sore throat, splenomegaly and lymphadenopathy. There is no specific criteria for the diagnosis of AOSD. Therapeutic regimens of AOSD include nonsteroidal anti-inflammatory drugs, glucocorticoids and immunosuppressants.