FICD activity and AMPylation remodelling modulate human neurogenesis
oleh: Pavel Kielkowski, Isabel Y. Buchsbaum, Volker C. Kirsch, Nina C. Bach, Micha Drukker, Silvia Cappello, Stephan A. Sieber
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Protein AMPylation is a post-translational modification whose implications in cellular physiology are not fully understood. Here the authors develop a cell-permeable AMPylation probe and use it to identify new AMP modified proteins and investigate the role of FICD in neuronal differentiation using cerebral organoids.