A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
oleh: Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev, Corinne Houart
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
SFPQ is a splicing factor and its mutations are associated to amyotrophic lateral sclerosis (ALS) patients. Here, the authors show that SFPQ represses the use of pathogenic cryptic last exons in zebrafish, mouse and human cells.