A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

oleh: Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev, Corinne Houart

Format: Article
Diterbitkan: Nature Portfolio 2021-03-01

Deskripsi

SFPQ is a splicing factor and its mutations are associated to amyotrophic lateral sclerosis (ALS) patients. Here, the authors show that SFPQ represses the use of pathogenic cryptic last exons in zebrafish, mouse and human cells.