Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fish, Monopterus albus
oleh: Qiaomu Hu, Zitong Lian, Xueping Xia, Haifeng Tian, Zhong Li
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2022-12-01 |
Deskripsi
Highlights DNA methylation modification plays a more crucial role than chromatin accessibility in gonad development. DNA methylation in the transcription start site plays a key role in gonad development. DNA methylation of the plastin-2 promoter inhibited gene expression. Plastin-2 is positively regulated by dmrt1 while negatively regulated by foxl2.