A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
oleh: Tiffany A. Thibaudeau, Raymond T. Anderson, David M. Smith
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
Disruption of the ubiquitin proteasome system (UPS) is often associated with neurodegenerative diseases. Here the authors demonstrate the existence of a general mechanism of proteasomal impairment triggered by a specific protein oligomer structure, irrespective of its protein constituent.