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The material for the study was the medical records of 40 patients with oropharyngeal cancer who had undergone cryogenic treatment at the N.N. Blokhin Russian Cancer Research Center in the period 1975 to 2009. Analysis of the long-term results of cryogenic treatment for primary cancer, recurrences, and traditional therapy-untreated tumor showed its efficacy in 60 % of the patients. Cancer recurrence occurred in 31 (25.8 %) patients who had completed the treatment: in 25.0 % of the primary patients and in 27.3 % of the patients with previous recurrences or previously untreated tumors. No local complications due to ipsilateral wound were noted. The cryogenic technique is recommended for use in oncological practice; its indications and contraindications in oropharyngeal cancer are defined.