Chiral 1H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
oleh: Chaofei Wu, Hongxin Liu, Juan Li, Hong-Ping Xiao, Xinhua Li, Jun Jiang
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2018-08-01 |
Deskripsi
A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0. 21 ppm ΔΔδ value. With this method, the optical purities of different non-racemic substrates can be fast evaluated with high accuracy.