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the irregularity of abstract and natural objectswith the fractal dimension. Fractal calculationshave been applied to the structures of the humanbody and to quantifications in physiology fromthe theory of dynamic systems.Material and Methods. The fractal dimensionswere calculated, the number of occupationspaces in the space border of box counting andthe area of two red blood cells groups, 7 normalones, group A, and 7 abnormal, group B, comingfrom patient and of bags for transfusion, werecalculated using the method of box counting anda software developed for such effect. The obtainedmeasures were compared, looking for differencesbetween normal and abnormal red blood cells,with the purpose of differentiating samples.Results. The abnormality characterizes by anumber of squares of occupation of the fractalspace greater or equal to 180; values of areasbetween 25.117 and 33.548 correspond to normality.In case that the evaluation according tothe number of pictures is of normality, must beconfirmed with the value of the area applied toadjacent red blood cells within the sample, thatin case of having values by outside establishedand/or the greater or equal spaces to 180, theysuggest abnormality of the sample.Conclusions. The developed methodology iseffective to differentiate the red globules alterationsand probably useful in the analysis of bagsof transfusion for clinical use.