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The aim of this study was to use Jumpstart Nutrition^&#174; bone supplementing combination with vitamin-K₂ and coenzyme-Q₁₀ characterized by an innovative delivery system that improves bioavailability of calcium-to-phosphorus ratio (CPR) and parathyroid hormone (PTH) in the management of osteoarthritis (OA). This eight-week registry included 108 patients treated for symptomatic OA confirmed with radiological images. On top of that, 63 patients used Jumpstart Nutrition^&#174; supplement, mainly prepared with calcium, phosphorus, coenzyme-Q₁₀, vitamin-K₂, vitamin-D₂, vitamin-C, folic acid, curcumin and boswellic acids. Rescue medication was also recommended. Patients&#8217; pain and functional capacity through outcome measures&#8212;knee-injury osteoarthritis outcome scale (KOOS) and Karnofsky performance scale (KPS), biomarkers such as levels of CPR, PTH and 25-hydroxy-vitamin-D were evaluated for the groups with and without supplement using appropriate kits. After eight weeks, the levels of CPR and PTH were all significantly improved (<i>p</i> &lt; 0.001), fewer subjects had to use rescue medication (<i>p</i> &lt; 0.05) and variation of pain and functional capacity under KOOS and KPS (<i>p</i> &lt; 0.05) of the patients in the supplement group compared to controls. This registry study indicates that Jumpstart Nutrition^&#174; can be used safely for effective management of OA patients for the amelioration of CPR, PTH and functional activities confirmed with biomarkers and radiological images correlated with the Kellgren-Lawrance scale.