Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]

oleh: Matilde Colella, Andrea Gerbino, Aldebaran M. Hofer, Silvana Curci

Format: Article
Diterbitkan: F1000 Research Ltd 2016-10-01

Deskripsi

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca2+ and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.