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Age-related macular degeneration(AMD)is a multifactorial- and polygenic-mediated chronic degenerative disease. Parainflammation is defined as a condition of tissue adaptive response to noxious stress or malfunction, it has features which are considered as intermediate between normal/basal and inflammatory/acute states. With the genetic predispositions, increased reactive oxygen species(ROS)generation cause the complement activation, placing the neuroretina-pigment epithelium-Bruch's membrane-choriocapillaris(NR-RPE-MB-CC)in the chronic condition of parainflammation which mediate apoptosis and angiogenesis, leading to AMD.