HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
oleh: Daniel Tarade, Claire M. Robinson, Jeffrey E. Lee, Michael Ohh
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
Hypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and propose a classification scheme for HIF-2α mutations that helps to predict disease phenotype outcome.