Atom Exchange Radical Cyclization: A Sustainable Synthetic Approach towards New Functionalized Targets

oleh: Biagio Anderlini, Andrea Severini, Camilla Ferrari, Claudio Fontanesi, Vittorio Ascari, Niccolò Braidi, Fabrizio Roncaglia

Format: Article
Diterbitkan: MDPI AG 2024-05-01

Deskripsi

In this study, we demonstrate the direct preparation of dihalo-<i>γ</i>-lactams featuring two distinct halogens from dichloroamides using a novel atom exchange radical cyclization (AERC) procedure. This method integrates the established atom transfer radical cyclization (ATRC) with halogen exchange in solution. The technique operates under mild conditions and requires small amounts of metallic copper, serving as both a supplemental activator and reducing agent.