Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
oleh: Kaiyuan Ni, Guangxu Lan, Christina Chan, Bryan Quigley, Kuangda Lu, Theint Aung, Nining Guo, Patrick La Riviere, Ralph R. Weichselbaum, Wenbin Lin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-06-01 |
Deskripsi
Radiotherapy is known to have local immunomodulatory effects, while an effective systemic immune response is an issue. Here, the authors report on nMOF radiosensitizers for enhanced radiotherapy which in combination with anti-PD-L1 antibodies result in a systemic immune response to distant tumors.