In vitro implementation of robust gene regulation in a synthetic biomolecular integral controller
oleh: Deepak K. Agrawal, Ryan Marshall, Vincent Noireaux, Eduardo D Sontag
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-12-01 |
Deskripsi
Feedback mechanisms for synthetic gene circuits are necessary to provide robustness to external perturbations. Here the authors validate a biomolecular controller based on a sigma and anti-sigma factor to achieve stable gene expression in the face of external disturbances in an in vitro synthetic gene circuit.