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We report a case of Klebsiella-related multidrug-resistant (MDR) postoperative endophthalmitis in a 60-year-old male treated successfully with colistin and core vitrectomy. Vision in the affected left eye (LE) at presentation was hand movements. Vitreous tap with intravitreal antibiotics (vancomycin and ceftazidime) showed no clinical improvement after 48 h. Gram stain of vitreous sample showed Gram-negative bacilli. Bacterial culture showed MDR Klebsiella pneumoniae isolates with sensitivity only to colistin. LE core vitrectomy was performed and intravitreal colistin was administered. At 1 month, vision in LE improved to 20/20 with no subsequent recurrence.