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Systemic lupus erythematosus is specially a disease of young women in their child bearing age. It has been found that SLE disease activity can repair in pregnancy even though patient is in complete remission state before the pregnancy. Besides this, pregnancy complications are higher in SLE patients. Another important issue is the use of drugs to control SLE because some of these drugs are potentially terotogenic. Fetal outcome is also a challenging issue. Therefore, multidisciplinary approach has key role in the management of Lupus pregnancy. Key words: Systemic lupus erythematosus (SLE); Lupus pregnancy; Lupus flare; Anti-phospholipid Antibody Syndrome; Neonatal Lupus Syndrome; Congenital heart block. DOI: 10.3329/bsmmuj.v3i1.5517 BSMMU J 2010; 3(1): 54-59