Dense and accurate whole-chromosome haplotyping of individual genomes

oleh: David Porubsky, Shilpa Garg, Ashley D. Sanders, Jan O. Korbel, Victor Guryev, Peter M. Lansdorp, Tobias Marschall

Format: Article
Diterbitkan: Nature Portfolio 2017-11-01

Deskripsi

Haplotype information is important in investigating many biological phenomena. Here, Porubsky et al. combine Strand-seq with long-read or linked-read sequencing to obtain complete and genome-wide haplotypes of a single individual genome at manageable costs.