Bis(zinc(II)-dipicolylamine)-functionalized sub-2 μm core-shell microspheres for the analysis of N-phosphoproteome
oleh: Yechen Hu, Bo Jiang, Yejing Weng, Zhigang Sui, Baofeng Zhao, Yuanbo Chen, Lukuan Liu, Qiong Wu, Zhen Liang, Lihua Zhang, Yukui Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-12-01 |
Deskripsi
N-phosphorylation plays a critical role in central metabolism and signaling processes, however, enrichment methods for N-phosphopeptides are limited by the P-N bond lability. Here, the authors report the synthesis and use of silica microspheres functionalized with bis(zinc(II)-dipicolylamine) in N-phosphopeptides effective enrichment.