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The aim of this research is to elucidate the projected bioclimatic conditions in the Mediterranean during midday and evening periods for both the near and far future under the representative concentration pathways, RCP4.5 (intermediate) and RCP8.5 (extreme). This analysis focuses on twenty pivotal tourist destinations, including Madrid, Barcelona, Palma de Mallorca, Nice, Tunis, Rome, Malta, Dubrovnik, Corfu, Methoni, Chalkidiki, Athens, Heraklion, Naxos, Rhodes, Istanbul, Alexandria, Antalya, Cairo, and Limassol. To quantify the current and projected bioclimatic conditions, the study employs the physiologically equivalent temperature (PET), which is based on the human energy balance. While the Mediterranean region is recognized as a hot spot for climate change, the distinctive bioclimatic patterns of individual locations are anticipated to exhibit notable variations, with consequential implications on tourism activities.