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We have developed an efficient diastereoselective synthesis of poly-substituted hydroquinolines from commercially available starting materials, Meldrum’s acid, aromatic aldehydes and arylamines, in a simple and one-pot reaction using Brønsted acidic ionic liquid (4-sulfobutyl)-tris(4-sulfophenyl) phosphonium hydrogen sulfate. These three materials react together through pseudo-eight-components reaction to generate complex products with four stereocenters that involves ten new bond formations. This synthetic method can be a combination of Knoevenagel and Michael reactions.