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Six new polyene carboxylic acids named serpentemycins E–J (<b>1</b>–<b>6</b>), together with three known analogs (<b>7</b>–<b>9</b>), were isolated from the fermentation medium of <i>Streptomyces</i> sp. TB060207, which was isolated from arid soil collected from Tibet, China. The structures of the new compounds were elucidated mainly on the basis of HR-ESI-MS and NMR spectroscopic analyses. The inhibitory activities of compounds <b>1</b>–<b>9</b> against NO production in LPS-activated RAW264.7 cells were evaluated. Compound <b>9</b> has an inhibition rate of 87.09% to 60.53% at concentrations ranging from 5.0 to 40.0 µM.