Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1
oleh: Prameladevi Chinnasamy, Isabel Casimiro, Dario F. Riascos-Bernal, Shreeganesh Venkatesh, Dippal Parikh, Alishba Maira, Aparna Srinivasan, Wei Zheng, Elena Tarabra, Haihong Zong, Smitha Jayakumar, Venkatesh Jeganathan, Kith Pradan, Jose O. Aleman, Rajat Singh, Sayan Nandi, Jeffrey E. Pessin, Nicholas E. S. Sibinga
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Macrophages have been reported to regulate thermogenic, sympathetic neuron-mediated norepinephrine signaling in adipose tissues. Here the authors report that male mice lacking the allograft inflammatory factor-1 protein are resistant to diet-induced obesity, in association with higher adipose norepinephrine levels and lower expression of the norepinephrine catabolic enzyme monoamine oxidase A.