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<p>A total of 153 patients with acute ischemic stroke were divided into diabetes group and non-diabetes group. Baseline characteristics and prognosis were observed and compared between patients of the 2 groups. The correlation between diabetes and outcome after intravenous thrombolysis was analyzed by multivariate stepwise Logistic regression analysis. The results showed that the patients in diabetes group accounted for less favorable outcome than that in non-diabetes group (26.83% vs 41.96%; <em>χ²</em> = 11.692, <em>P</em> = 0.001) at 90 d after thrombolytic treatment. Logistic regression analysis indicated that diabetes was relevant to unfavorable outcome of ischemic stroke (<em>OR</em> = 1.224, 95% CI: 1.034-1.449; <em>P </em>= 0.019). The results illustrate that diabetes is highly relevant to unfavorable outcome of thrombolytic patients with acute ischemic stroke.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.11.018</p>