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The objective of the current experiment was to describe the effects of nano-chromium chloride (CrCl3) on chronic hyperthermia (32.8 ± 1.5 °C) on rabbit liver, kidney, and appendix in comparison with rabbits at room temperature (24.5 ± 1.3 °C) and treated with the same concentration of nano-chromium chloride. For this study, 108 rabbits of two different breeds (New Zealand White and Rex) were used and randomly allocated into 12 groups. The study was conducted as a completely randomized 2 × 2 × 3 factorial (n = 9) design. Treatments were temperature, breed, and concentration of nano-chromium chloride (0, 1, or 2 mg/L) the results showed that heat stress caused granular hepatic vacuolation, severe congestion of the central vein, and sinusoids in the liver. As well as degenerative changes within the epithelial lining of tubules in the kidney and lymphoid depletion in the appendix. The liver tissue of the New Zealand rabbits was affected more by heat stress than Rex Rabbits, but no difference was observed in the kidney or appendix tissues. The addition of 2 mg/L nano-chromium was more effective than 1 mg/L on the heat stressed rabbit tissues, but it caused hepatic vacuolation with glycogen infiltration in liver tissue and mild vacuolation in the renal tubular epithelium. Key words: rabbit; nano-chromium; heat stress; histopathology