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Systemic lupus erythematosus (SLE) is an inflammatory disease of unknown etiology. In the pathogenesis of SLE, several infectious agents have been held responsible such as cytomegalovirus, parvovirus B19 and Epstein Barr virus (EBV). There is a variable relationship between SLE and helicobacter, which is different from that of lupus and other infections. We would like to emphasize the interrelation between these entities. [Med-Science 2015; 4(2.000): 2344-7]