Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics
oleh: María Gordillo-Marañón, Magdalena Zwierzyna, Pimphen Charoen, Fotios Drenos, Sandesh Chopade, Tina Shah, Jorgen Engmann, Nishi Chaturvedi, Olia Papacosta, Goya Wannamethee, Andrew Wong, Reecha Sofat, Mika Kivimaki, Jackie F. Price, Alun D. Hughes, Tom R. Gaunt, Deborah A. Lawlor, Anna Gaulton, Aroon D. Hingorani, Amand F. Schmidt, Chris Finan
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
Drug target Mendelian randomization (MR) uses genetic variation in or near a gene encoding a drug target to anticipate the effect of drug action on the same target. Using drug target MR, the authors prioritized 30 targets that might elicit beneficial effects in the prevention or treatment of coronary heart disease.