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Back ground: Malaria is the most common cause of hemolytic anemia and other causes of anemia include defective erythropoiesis and reticulocyte production. Other hematological complications include thrombocytopenia and platelet dysfunction. Coagulopathy abnormalities are also in severe malaria Objectives: To study complications of falciparum malaria. Material and methods: A total of 100 cases of laboratory confirmed and admitted cases of falciparum malaria during the study period of two years, who fulfilled inclusion and exclusion criteria were studied. Complete relevant history, thorough clinical examination was carried out to assess complications. Results: The most common complication of falciparum malaria was renal and hepatic involvement. Among 31 patients with complications, 17 had single complication, 5 had two complications, 5 had three complications, and 4 patients had 4 complications. Elevated blood urea and creatinine was noted in 18 patients among 100 cases .Out of them 88.8 % had longer duration of hospital stay. Elevated bilirubin levels were seen in 18 patients. Conclusion: Falciparum malaria is associated with other complications which include cerebral malaria, renal involvement, hepatopathy, respiratory manifestations, which may lead to increase in the mortality if not detected early and treated properly and adequately.