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This article mainly examines the effect(s) of legal drug misuse on work absenteeism, which has a connecting influence to work productivity. Also, the analysis compares the effects of legal drug use (e.g., tranquilizers) on work absences to that of a commonly used, but illegal drug, marijuana. Utilizing a large dataset from the NSDUH (National Survey on Drug Use and Health), and controlling for several demographic and labor market-related variables, our results indicate that legal drug use (for nonmedical reasons) leads to an increase in work absenteeism, as does marijuana. In some instances, legal drug use has a greater effect on work absenteeism that does marijuana.