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Most of the patients with diabetes and hypertension should be treated with a systolic blood pressure <140 mmHg/ and diasto- lic BP of <90 mmHg. Lower levels of BP <130/80 mmHg can be adequate in patients with high risk of heart and kidney diseases. Angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARA II) at maximum tolerated doses are considered first line drugs in the treatment of hypertension, in diabetic patients with a rate of albuminuria/creatininuria >30 mg/g serum creatinine, the level of glomerular filtration and the level of potassium should be monitored. Different studies observe with these drugs, nephroprotection regardless of the reduction of attained blood pressure. It is not recommended to use a of ACEI and ARA II combination. Calcium channel inhibitors are safe drugs for the treatment of hypertension in diabetic patients, with kidney insufficiency.