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Escherichia hermannii is a microorganism very rarely isolated from clinical specimens, since its first identification in 1982. So far, there are around 17 human cases reported in medical sources. This small number of isolated case, eventually leads to a lack of information about the pathology and pathogenesis of infections caused by this microorganism. In the present article, we report a diabetic foot co-infection due to Escherichia hermannii and Enterobacter aerogenes. The treatment of the patient was started with a combination of empiric piperacillin/tazobactam and teicoplanin therapy. Later, based on the microbiology test results, this medication was converted to meropenem. When the patient’s septic condition improved, coronary artery bypass and transtibial amputation operations were performed. The patient recovered completely and was discharged without further issues. To the best of our knowledge, this is the first E. hermannii infection report from Cyprus and the Middle East.