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<p><strong>Objective</strong> To explore the clinical value of repairing skull defects with titanium alloy-mesh of computer-aided design.  <strong>Methods</strong> A retrospective analysis was done on clinical data of 86 cases with skull defects who underwent repairing using titanium mesh with two-dimensional or three-dimensional computer-aided design.  <strong>Results</strong> All the incisions achieved primary healing other than one case conducting reoperation due to exposed titanium mesh. Two cases got subcutaneous exudate, one obtained painful mastication and one experienced proliferation of scalp scar. <strong> Conclusions</strong> With the computer-aided designated titanium mesh, relevant operation can resume the original state to maximum extent, lower surgical risk, decrease post-operational complications and then obtain satisfying clinical effect.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.01.015</p>