Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

oleh: Ryan S. Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir, Kris C. Wood

Format: Article
Diterbitkan: Nature Portfolio 2018-08-01

Deskripsi

Dependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3 mimetics