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Spatial analysis is essential to understand the spreading of the COVID-19 pandemic. Due to numerous factors of multi-disciplines involved, the current pandemic is yet fully known. Hence, the current study aimed to expand the knowledge on the pandemic by exploring the roles of forests and CO₂ emission in the COVID-19 case-fatality rate (CFR) at the global level. Data were captured on the forest coverage rate and CO₂ emission per capita from 237 countries. Meanwhile, extra demographic and socioeconomic variables were also included to adjust for potential confounding. Associations between the forest coverage rate and CO₂ emission per capita and the COVID-19 CFR were assessed using spatial regression analysis, and the results were further stratified by country income levels. Although no distinct association between the COVID-19 CFR and forest coverage rate or CO₂ emission per capita was found worldwide, we found that a 10% increase in forest coverage rates was associated with a 2.37‰ (95%CI: 3.12, 1.62) decrease in COVID-19 CFRs in low-income countries; and a 10% increase in CO₂ emission per capita was associated with a 0.94‰ (95%CI: 1.46, 0.42) decrease in COVID-19 CFRs in low-middle-income countries. Since a strong correlation was observed between the CO₂ emission per capita and GDP per capita (r = 0.89), we replaced CO₂ emission with GDP and obtained similar results. Our findings suggest a higher forest coverage may be a protective factor in low-income countries, which may be related to their low urbanization levels and high forest accessibilities. On the other hand, CO₂ can be a surrogate of GDP, which may be a critical factor likely to decrease the COVID-19 CFR in lower-middle-income countries.