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Recently, bioprospecting of marine actinomycetes has attracted because of the exploration of novel metabolites with promising biological applications such antibacterial, antimicobacterial antioxidant. Therefore, the present study has been aimed to explore the isolation and characterization promising marine actinomycetes from the Jazan region of Saudi Arabia and metabolite profiling of the extracellular metabolites together with assessment of anti-bacterial, anti-tubercular and anti-oxidant potentials. The extracellular metabolites were profiled using gas chromatography coupled with mass spectrum and MIC and MBC values of the fractions were evaluated by broth microdilution techniques. Biochemical, micromorphological and 16S rRNA gene analysis study clearly confirmed that the promising strain Al-Dbabi-100 belonged to the genus Streptomyces. MIC values of the fraction noted as 62.5 µg/ml for E. faecalis, 31.25 µg/ml for B. subtilis, 125 µg/ml for S. aureus, 250 µg/ml for S. epidermidis and 125 µg/ml for K. pneumoniae respectively and cell growth inhibition study resulted 19.78%,71.4% and 91.6% inhibition towards K. pneumoniae, E. coli and P. aeruginosa pathogens. Interestingly, the fraction revealed promising antitubercular and antioxidant activities. GCMS analysis showed 1-(2,6-Dimethyl-4-propoxyphenyl)propan-1-one (7%) and ethyl 2-propylphenyl ester (11.9%) as the major compounds. Keywords: Marine actinomycetes, Antibacterial, Anti-tubercular, Antioxidant