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Blood cancer has become quite common in all age groups, worldwide. The cancer ranges from acute life threatening leukemias to indolent chronic leukemias, Lymphoma spillovers causing morbidity and mortality to slow-growing indolent lymphomas. Since blood is present everywhere in the body hence the spread of hematological malignancies is massive. Chemotherapy is expensive and a must to treat blood cancers. However, the ancillary workups like flowcytometry etc in prognosticating and diagnosing blood cancers become quite cumbersome and heavy on the pocket for an average Indian. Therefore, the authors planned the study aimed at analyzing- -Trend in NLR,LMR, PLR RDW, Platelet count at baseline -Trend in NLR,LMR, PLR RDW, Platelet count 2 months post-chemotherapy -Comparison between 2 parameters for any significant change The study was carried out on 11 cases as a prospective case-based study of 11 cases where pre and post-values of chemotherapy cases of newly diagnosed blood cancer cases were available with the author. The baseline CBC and post-induction 1 st CBC were used to record the variables under study and latest SPSS software was used to come to a conclusion through the results. The findings stated that there was a decline in NLR, PLR and platelet count at follow-up as compared to baseline and an increase in LMR and RDW at follow-up as compared to baseline, however, the difference was significant statistically only for PLR (p=0.028) and near significant (p=0.059) for platelet count. Hence in view of significant findings seen only in 11 cases a larger cohort may be used to correlate these findings with follow up of such cases.