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Role of exosomal noncoding RNA in esophageal carcinoma
oleh: Mao-Yan Si, Ding-Yu Rao, Yao Xia, Cheng-Peng Sang, Kai-Yun Mao, Xiang-Jin Liu, Zu-Xiong Zhang, Zhi-Xian Tang
Format: | Article |
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Diterbitkan: | Frontiers Media S.A. 2023-05-01 |
Deskripsi
Esophageal cancer is a common malignant tumor with a high degree of malignancy. Understanding its pathogenesis and identifying early diagnostic biomarkers can significantly improve the prognosis of esophageal cancer patients. Exosomes are small double-membrane vesicles found in various body fluids containing various components (DNA, RNA, and proteins) that mediate intercellular signal communication. Non-coding RNAs are a class of gene transcription products that encode polypeptide functions and are widely detected in exosomes. There is growing evidence that exosomal non-coding RNAs are involved in cancer growth, metastasis and angiogenesis, and can also be used as diagnostic and prognostic markers. This article reviews the recent progress in exosomal non-coding RNAs in esophageal cancer, including research progress, diagnostic value, proliferation, migration, invasion, and drug resistance, provide new ideas for the precise treatment of esophageal cancer.