Chaperone mediated detection of small molecule target binding in cells
oleh: Kelvin F. Cho, Taylur P. Ma, Christopher M. Rose, Donald S. Kirkpatrick, Kebing Yu, Robert A. Blake
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess cellular target engagement and identify new drug targets.