Scalalactams A–D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean <i>Spongia</i> Sp. Marine Sponge
oleh: Inho Yang, Jusung Lee, Jihye Lee, Dongyup Hahn, Jungwook Chin, Dong Hwan Won, Jaeyoung Ko, Hyukjae Choi, Ahreum Hong, Sang-Jip Nam, Heonjoong Kang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2018-12-01 |
Deskripsi
Intensive study on the chemical components of a Korean marine sponge, <i>Spongia</i> sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A⁻D (<b>1</b>⁻<b>4</b>). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A⁻D (<b>1</b>⁻<b>4</b>) possess a scalarane carbon skeleton with a rare structural feature of a γ-lactam moiety within the molecules. Scalalactams A and B (<b>1</b> and <b>2</b>) have an extended isopropanyl chain at the lactam ring, and scalalactams C and D (<b>3</b> and <b>4</b>) possess a phenethyl group at the lactam ring moiety. Scalalactams A⁻D (<b>1</b>⁻<b>4</b>) did not show FXR antagonistic activity nor cytotoxicity up to 100 μM.