Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
oleh: Federica Cella, Liliana Wroblewska, Ron Weiss, Velia Siciliano
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
RNA-encoded regulatory circuits are desirable because they do not integrate in the host and are less immunogenic, but the availability of regulatory devices is limited. Here the authors develop viral protease RNA-binding proteins and protease–protease genetic circuits that ultimately regulate mRNA translation.