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A 20-year-old woman presented with a 2-day history of seizure. The physical examination revealed no neurological deficit. Radiological imagings showed a large tumor on the right frontal skull base. Thetumor was surgically removed. Histopathology confirmed the diagnosis of schwannoma. Immunohisto-430 chemical studies revealed that the tumor cells were positive for S-100 protein and negative for both epithelial membrane antigen (EMA) and Leu7. One year later magnetic resonance imaging (MRI) showed no recurrent tumor. Solitary schwannoma arising from the anterior skull base is rare and less than 35 cases have been reported in the literature.