A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer
oleh: Manijeh Goldberg, Aaron Manzi, Peter Conway, Stefanie Cantin, Vasudha Mishra, Alka Singh, Alexander T. Pearson, Eric R. Goldberg, Sam Goldberger, Benjamin Flaum, Rifat Hasina, Nyall R. London, Gary L. Gallia, Chetan Bettegowda, Sonya E. O’Neill, Erkin Aydin, Alex Zhavoronkov, Anxo Vidal, Atenea Soto, Maria Jose Alonso, Ari J. Rosenberg, Mark W. Lingen, Anil D’Cruz, Nishant Agrawal, Evgeny Izumchenko
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Cisplatin is the most frequently used chemotherapeutic agent for the treatment of patients with oral cavity squamous cell carcinoma (OCSCC), however, systemic administration is often associated with dose limiting side effects. Here the authors design and test a nano-engineered patch system (PRV111) for the local delivery of cisplatin-loaded chitosan nanoparticles and report the results of a phase 1/2 clinical trial of PRV111 in patients with OCSCC.