RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome
oleh: Kevin T. Urak, Giselle N. Blanco, Shambhavi Shubham, Li-Hsien Lin, Justin P. Dassie, William H. Thiel, Yani Chen, Vijay Kumar Sonkar, Beilei Lei, Shubha Murthy, Wade R. Gutierrez, Mary E. Wilson, Jonathan A. Stiber, Julia Klesney-Tait, Sanjana Dayal, Francis J. Miller, Paloma H. Giangrande
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
Multiple organ dysfunction syndrome (MODS) is a serious event that can occur following infection or tissue injury, and is partly mediated by histones released in circulation. Here, the authors develop aptamers that neutralise histones involved in MODS, and demonstrate efficacy in human cells and in mouse models.