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This review presents the current possibilities of diagnosis of children’s liver disease: to define avidity of antibodies to hepatitis A, C for detection early infection, the development of non-invasive panel of serum markers of fibrosis and the introduction of elastography liver, as an alternative to needle biopsy. Indicated promising directions in the therapeutic tactics of viral hepatitis in children associated with the use of combined schemes of parenteral interferon (IF), including pegylated, in conjunction with similar nukleoz(t) ides, IF inducers.