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Severe acute respiratory syndrome corona virus 2 acts through angiotensin converting enzyme-2 (ACE-2) receptors and involves multiple organ systems. Also associated with many upper airway symptoms, we reported an unnoticed complication of the upper airway, which presented as hoarseness of voice and throat discomfort during ICU stay, the upper airway flexible endoscopy was performed, which showed vocal cord nodule. The patient was managed conservatively, by improving hydration, steam inhalation, voice rest, and speech therapy. Gradually, there was a significant improvement in patient's symptoms and voice quality. An early prediction and risk mitigation can prevent this complication.